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Datenauswertung 34 5. Bildanalyse 34 5. Histopathologische Datenauswertung 40 5. Statistische Analyse 45 6. ROC-Analyse 48 7. Kein Nachweis 53 7.

Partialvolumeneffekt 57 7. ROC-Analyse 71 11 7. Patientenpopulation 76 8. Statistische Verfahren 77 9. Das mittlere Alter der Diagnose liegt bei Im Zeitraum von bis betrug die Inzidenz in Deutschland ca.

Tabelle I. Sun et al. Wefer et al. Unter diesen stellt die funktionelle Bildgebung eine vielversprechende Option dar.

Sie wird jedoch nicht als Firstline- 11 Diagnostikum angewandt, da sie sich noch in Entwicklung befindet und somit Limitationen aufweist Rajesh et al.

Eine FDG-Anreicherung zeigt sich regelhaft nur in entdifferenzierten aggressiven und metastasierten Prostatakarzinomen Oyama et al.

Dieses Ergebnis wurde auch von Scher et al. Auch Farsad et al. Scher et al. HGPIN 4. Grundlagen 4. In einer Studie von Mullerad et al.

Bloch et al. Sella et al. Der aus den gemessenen Konzentrationen berechnete Cholin-u. Diese Beobachtung wird von Scheidler et al.

MRS bei alleiniger Anwendung Scheidler et al. Genanntes Ergebnis wird ebenso von Yamaguchi et al. Jung et al. Studien haben gezeigt, dass residuelles bzw.

Des weiteren wiesen Yamaguchi et al. Abbildung I. Die im Material deponierte Energie der Quanten wird in einem - bei den heute klinisch eingesetzten Tomographen - vornehmlich anorganischen Szintillationskristall in sichtbares Licht umgewandelt.

Zur Verbesserung der Nachweisempfindlichkeit der Gammaquanten, die sich bei der Koinzidenzmessung aus dem Produkt Kernladungszahl der und beiden Dichte Einzelempfindlichkeiten des Szintillators berechnet, wichtig.

Das vom Szintillatorkristall emittierte Licht wird von direkt gekoppelten Photosensoren in Form von Photomultipliern registriert.

Hierbei wird das auftreffende Licht an der Kathode der Photomultiplier in Elektronen konvertiert, welche in mehreren Dynodenstufen vervielfacht werden.

Die Amplitude des an der Anode abgegriffenen Signals ist direkt 21 proportional zu der im Kristall deponierten Energie.

Die Photomultipliersignale werden im Zuge der Elektronikweiterentwicklung unter Einsatz von Analog-zu-Digital-Wandlern digitalisiert; weitere technische Komponenten der PET sind eine angepasste Ausleseelektronik und Bildverarbeitungsrechner.

Es wurden weitere Methoden entwickelt, unter denen in der klinischen Routine heute vornehmlich der sog. Abbildung II.

Abbildung III. Der Glukosemetabolismus wird von Faktoren wie Tumorzellcharakteristika und unterschiedlichen Wachstumsbedingungen beeinflusst.

Jadvar et al. Auch Agus et al. Hofer et al. Oyama et al. Larson et al. Nunez et al. Kato et al. Kotzerke et al.

Die Autoren Wachter et al. Abbildung IV und letztlich in die Phopholipidmembran eingebaut. Diese resultiert u.

Im Gegensatz zu [18F]-markierten Cholinderivaten, die auch im Satellitenkonzept einsetzbar sind, ist der Einsatz von [11C]Cholin auf Kliniken mit Zyklotron und Radiopharmazie begrenzt, bedingt durch die kurze Halbwertszeit von [11C]Cholin.

Sie werden nach spezifischem Transport durch Cholintransporter durch die Cholinkinase phosphoryliert. Patienten, Material und Methoden 5.

Patienten mit begleitenden anderen Krebserkrankungen wurden nicht in die Studie aufgenommen s. Tabelle II. Die Ethikkommission gab ihr positives Votum zur Studie, alle Patienten stimmten schriftlich der Teilnahme an der Studie zu.

Pascali et al. Die Kartusche wurde direkt mit Dimethylaminoethanol beladen. Die Nummerierung erfolgte im Uhrzeigersinn beginnend bei Abbildung V.

Abbildung VI. Abbildung VII. Abbildung VIII. Abbildung IX. Abbildung X. Die Schnitte wurden alphabetisch von basal nach apikal mit Buchstaben benannt s.

Abbildung XI. Abbildung XII. Abbildung XIII. Anhand anatomischer Strukturen, wie z. Bei der Fusion der prozentualen Anteile bzw.

Ergebnisse In der Segmentanalyse wurden insgesamt 2. Abbildung XIV. Hierunter waren 8 von 8 in Gruppe 4 klassifiziert, 2 von 5 in Gruppe 3, 1 von 9 in Gruppe 2 und 3 von 21 in Gruppe 1.

Tabelle 46 III. Abbildung XV und 0. Ein Cut-off-Wert von 5. Bei Aufteilung der Tumoren nach Stadien in T2 bzw. Diskussion 7.

Tabelle IV : De Jong et al. Karzinome zeigten in ihrer Studie einen mittleren SUV von 2. Aufgrund dieser Ergebnisse befanden De Jong et al.

In ihrer Studie wiesen Sutinen et al. Kwee et al. Unter den 17 untersuchten Patienten hatten 11 bilateral und sechs unilateral positive Befunde in der Biopsie.

In einer prospektiven Studie verglichen Yamaguchi et al. Yoshida et al. Auch Schmid et al. Tabelle IV. Farsad et al. In einer Studie von Scher et al.

Ebenso untersuchten Martorana et al. Der einzige Parameter, der bei Martorana et al. Die Autoren Giovacchini et al. Es Prostatektomie und wurden 19 histologischer sextantenbasierter Analyse untersucht und sechs Patienten vor und nach anti-androgener Hormontherapie.

In der Studie von Farsad et al. Zudem zeigten Farsad et al. Wie Farsad et al. Auch in der Studie von Schmid et al. Ein Fakt, der sich unter anderem darin zeigte, dass maligne Prozesse der Prostata, die in der apicoanterior-peripheren oder transitionalen Zone lokalisiert waren, oftmals in der konventionellen Bildgebung nicht erfasst wurden, was sich in falsch-negativen Befunden der TRUS-gesteuerten Biopsien widerspiegelte Yoshida et al.

Martorana et al. Frimmel et al. Daneshgari et al. Prostatitis hatte daher aufgrund mangelnder Signifikanz bei der Differenzierung Einfluss auf die Karzinomdetektion.

Eine Unterscheidung des Karzinoms bzw. Reske et al. Die Ergebnisse von Reske et al. Die Studie von Scher et al. KoriAeenje Vodnih Menadment i Tehno Merenja u Hidrote Navodnjavanje Plovni Putevi i P Regulacija Reka Vodoprivredni Sis Dinamika Konstruk Izborni Predmeti Menadment i tehno Metod konacnih el Prethodno Napregn Primena RaAeunara Geoinformacioni S GraAeevinska Ekon Tehnologija GraAe Teorija Menadment Ugovaranje u GraA Upravljanje Proje CAD u Projektovan Gornji Stroj elez Izborni Predmeti Kolovozne Konstru Odravanje elezniA Odravanje Puteva Planiranje i Proj Peta Godina Odsek za Geodezij Odsek za Hidroteh HidrotehniAeke Gr Izborni Predmeti NumeriAeke Metode Betonski Mostovi Brane Ispitivanje Konst Odsek za Menadment Odsek za Puteve

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